On January 3 2022 at 20:47 UTC Microsoft began blocking mail sent from smtp.de.opalstack.com to domains that use the Microsoft 365 email system.
Microsoft's own IP reputation and junk mail reporting systems indicate that there are no problems with smtp.de.opalstack.com so we've reached out to them for answers.
We'll update this post as soon as more information is available.
In the interim as a possible workaround customers may create a new mailbox on our US mail server and use that temporarily for their outgoing email authentication.